The investigation of chemistry at the single-molecule level provides reaction details that are masked in ensemble experiments. The use of engineered protein nanopores as nanoreactors allows individual bond-making and bond-breaking events to be monitored in real time, which modulate the voltage-driven ionic current through a pore. Yujia’s research focuses on studying single-molecule chemistry, particularly that of polymers, under nanopore confinement. The chemical insights gained at the molecular level has been applied to construct a mobile molecule, which can move biopolymers within a nanopore sensor for sequence analysis. In parallel, Yujia is interested in engineering protein nanoreactors to achieve vectorial catalysis.